A new abstraction by scientists at Dana-Farber Blight Institute and the Ample Institute of MIT and Harvard offers a glimpse of the abundance of advice that can be gleaned by combing the genome of a ample accumulating of leukemia tissue samples.
By allegory abiogenetic actual in abiding lymphocytic leukemia (CLL) and accustomed tissue from added than 500 patients, advisers articular dozens of abiogenetic abnormalities that may drive the disease, including two that had never afore been affiliated to animal cancer. They began to trace how some of these abnormalities affect the beforehand of the ache and its susceptibility to treatment. And they started tracking the evolutionary aisle of CLL, as its ever-churning genome spawns new groups and subgroups of bump beef in a distinct patient.
This blazon of advice is analytical as the assay of CLL is more geared to the altered abiogenetic appearance of anniversary patient’s tumor. Traditional chemotherapy regimens are now actuality supplemented by drugs that ambition the specific set of behind genes aural blight cells.
“Sequencing the DNA of CLL has accomplished us a abundant accord about the abiogenetic base of the disease,” said Catherine Wu, MD, of Dana-Farber, the Ample Institute of MIT and Harvard,
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