Background/aims: Since December 2002 we use ibuprofen to amusement PDA. Success rates, however, were lower than expected. We accordingly compared ability and ancillary furnishings of ibuprofen in actual low bearing weight breed to a actual ascendancy accumulation advised with indomethacin.
Methods: Charts of all breed < 1500g accepted from 1.1.2000 to 1.3.2005 were reviewed. Breed mechanically aerial on day 3 of life, with echocardiographically accepted PDA accustomed indomethacin (3 x 0.2 mg/kg in 12 hours intervals; time aeon 1: afore 1.12.2002) or ibuprofen (10; 5; 5 mg/kg in 24 hours intervals; time aeon 2. afterwards 1.12.2002), respectively.
Results: Fifty-three (25%) of 214 breed built-in in time aeon 1 were advised with indomethacin. Median bearing weight 830 g (380 – 1460), gestational age 26 wks (22 – 31). Fifty-six (36%) of 155 breed were advised with ibuprofen. Median bearing weight 895 g (355 – 1430), gestational age 26 wks (23 – 30). Closure ante with aboriginal analysis aeon were 60% (indomethacin) and 34% (ibuprofen) (p=0.005). Surgical articulation was performed in 7% of breed during time aeon 1 against 14% in time aeon 2 (p=0.02). Temporary oliguria/anuria occurred in 19% of breed in the indomethacin and in 11% in the ibuprofen analysis group. Focal abdominal breach or NEC with breach occurred during time aeon 1 in 4/
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